Anthony T Maurelli

Anthony T Maurelli,


Department: Department of Environmental and Global Health
Business Phone: (352) 294-5029
Business Email:

About Anthony T Maurelli

Anthony T. Maurelli, Ph.D. is Professor of Environmental and Global Health. He received a B.S. in Biology from Villanova University, Villanova, PA in May 1974 and a Ph.D. in Molecular Cell Biology in June 1983, from the University of Alabama in Birmingham, Birmingham, AL under the direction of Dr. Roy Curtiss III. After his Ph.D. work, Dr. Maurelli spent three years as a Postdoctoral Fellow and Chargé de Recherche with Prof. Philippe Sansonetti in the Service des Entérobactéries at the Institut Pasteur, Paris, France.

In 1986, Dr. Maurelli accepted a position of Assistant Professor in the Department of Microbiology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD. He was promoted to Associate Professor (with tenure) in 1992 and then to Professor in 1999. He held joint appointments as graduate faculty in the Molecular and Cell Biology and Emerging Infectious Diseases Graduate programs. Dr. Maurelli joined the Department of Environmental and Global Health, College of Public Health and Health Professions, and the Emerging Pathogens Institute (EPI), University of Florida in January 2016. He is also affiliate graduate faculty of the Molecular Genetics and Microbiology Department of the University of Florida College of Medicine.

Dr. Maurelli is an elected Fellow of the Infectious Diseases Society of America and the American Academy of Microbiology. He has served as Secretary-Treasurer of the Chlamydia Basic Research Society and Mini-reviews Editor for Infection and Immunity. Dr. Maurelli directs an active, NIH-funded basic research program in his laboratory at the EPI in Gainesville . He has had continuous funding from the NIH for over 25 years.


University of Florida Faculty Enhancement Opportunity Award
2023 · University of Florida
Keynote Address
2018 · 62nd Annual Wind River Conference on Prokaryotic Biology, Estes Park, Colorado
Inducted into Beta Upsilon Chapter of Delta Omega Honorary Society in Public Health
2017 · Beta Upsilon Chapter of Delta Omega Honorary Society in Public Health, University of Florida
Elected Secretary-Treasurer
2015 · Chlamydia Basic Research Society
Keynote Address
2015 · German Chlamydia Workshop, Vienna, Austria
Elected Fellow
2008 · American Academy of Microbiology
The Arkansas Medical Society Distinguished Speaker Lecture Series
2008 · University of Arkansas for Medical Sciences
Henry Wu Award for Excellence in Basic Science Research
2004 · Faculty Senate Research Day, Uniformed Services University
Infectious Diseases Society of America
2000 · Elected Fellow

Teaching Profile

Courses Taught
PHC7979 Advanced Research
PHC6917 Supervised Research Project
PHC6900 Environmental and Global Health Journal Club
PHC6722 Environmental and Global Health Research Methods Rotation
PHC6947 Environmental and Global Health Capstone Experience
PHC6937 Special Topics in Public Health
PHC6601 Seminar in Contemporary Public Health Issues
PHC6946 Public Health Internship
VME7979 Advanced Research
GMS7979 Advanced Research
HSC4930 Special Topics
PHC6671 Emerging Infectious Diseases in One Health
PHC6941 MPH Applied Practice Experience
HSC4913 Supervised Research Experience
PHC7980 Research for Doctoral Dissertation
PHC4320 Environmental Concepts in Public Health

Research Profile

Dr. Maurelli has over 30 years of research experience in the field of molecular genetics of bacterial pathogenesis, specifically in the study of Shigella and Chlamydia. Shigella is the causative agent of bacillary dysentery and globally is one of the most common causes of severe diarrhea in children less than 5 years of age. Chlamydia is a major cause of sexually transmitted infections worldwide. It also causes pneumonia and ocular infections and is the leading cause of preventable blindness.

Shigella pathogenesis – Among his many contributions in this field, Dr. Maurelli discovered temperature regulation of virulence genes in Shigella, cloned and identified the genes required for invasion of mammalian cells, identified the first genes of what came to be known as the type III secretion system and provided the first evidence for secretion of virulence effectors from Shigella, defined the concept of pathoadaptation by gene loss in the evolution of bacterial pathogens from commensal ancestors (the evolution of “black holes” in Shigella), described the anti-apoptosis phenotype of pathogenic Shigella, and identified emerging Shiga toxin-producing strains of Shigella flexneri with an epidemiological link to Hispaniola. On-going research in the Maurelli Lab focuses on defining how the loss of certain genes in Shigella gives the bacterium a selective advantage within or outside the human host. Another project seeks to understand the evolution and public health consequences of the recently emerging group of non-Shigella dysenteriae Shigella strains that produce Shiga toxin. Epidemiological evidence points to the emergence of these strains from Haiti and the Dominican Republic. Future studies aim to identify potential sources and reservoirs of these strains in Haiti and the Dominican Republic. Since the genes for Shiga toxin are carried by a bacteriophage (viruses that attack bacteria), field studies are also planned to search for these bacteriophages in water sources in Haiti and the Dominican Republic.

Chlamydia pathogenesis – The Maurelli laboratory has conducted NIH-funded research on this important pathogen since 1998. Some of the significant discoveries made by his research team over this period are the first demonstration of directed allelic exchange in Chlamydia in the laboratory setting and, identification and characterization of transporters for biotin, NAD, and a novel transporter of S-adenosyl methionine. In addition, the Maurelli Lab has made major contributions to our understanding of Chlamydia peptidoglycan (cell wall) synthesis including: the first demonstration of a functional gene in the pathway of peptidoglycan synthesis in Chlamydia; discovery and characterization of an alternative pathway for synthesis of diaminopimelic acid (a unique and critical component of bacterial cell walls); use of metabolic labeling to demonstrate the presence of peptidoglycan in C. trachomatis, and resolution of its chemical structure. These latter discoveries resolved a 50 year old paradox of Chlamydia biology, i.e. the sensitivity of the organism to antibiotics that inhibit peptidoglycan synthesis but the absence of any detectable peptidoglycan. The Maurelli Lab continues to study the pathway for peptidoglycan synthesis and the role it plays in bacterial growth and cell division. Since peptidoglycan fragments are potent ligands for stimulation of innate immune responses, the mechanisms of its turnover and the effects of Chlamydia peptidoglycan fragments on host cell signaling are also being examined. Another project focuses on the study of how Chlamydia acquires essential nutrients such as iron and small peptides from its host.

Public Health – The UF-EPI Haiti Lab 1-Gressier was the first site of a surveillance project to measure the prevalence of sexually transmitted infections (STI) in the adult population in an urban population in Haiti. A satellite UF-EPI lab was also established in the rural mountain community of Baradères for this study. Participants were recruited, consented and tested for four major STIs: chlamydia, gonorrhea, syphilis and trichomoniasis. They also were given a questionnaire on sexual behavior, risk factors, and mobility. Data from these surveys can be used by local stakeholders to develop effective interventions to reduce the incidence of STIs. Another project focuses on studying the evolution and public health consequences of a recently emerging group of Shigella strains that produce a potent toxin, Shiga toxin (see section on Shigella above). These strains have been isolated from travelers returning to the U.S., Canada, and France from Haiti and the Dominican Republic. The same strains have also been isolated from Haitian children attending a school near the UF-EPI Haiti lab in Gressier. Future projects will focus on understanding Haitians’ knowledge, attitudes and practices with respect to water, particularly as it relates to infectious diseases. In response to the COVID-19 pandemic, the Maurelli Lab, in collaboration with other faculty in EGH, developed methods for detection of SARS-CoV-2 in wastewater. Measurement of virus levels in wastewater has been done in municipal water systems and on the University of Florida campus. Additional public health projects in the areas of wastewater-based epidemiology, water quality, and infectious diseases are available for undergraduate and graduate student projects.

Areas of Interest
  • Bacillary dysentery
  • Bacterial cell division
  • Bacterial cell wall
  • Bacterial genetics
  • Bacterial pathogenesis
  • Bacterial physiology
  • Chlamydia
  • Emerging infectious disease
  • Evolution of bacterial pathogens
  • Global Health
  • Infectious disease surveillance
  • One Health
  • Pathoadaptation
  • Peptidoglycan
  • Sexually transmitted infections
  • Shiga toxin
  • Shigella
  • Transport systems in bacteria
  • Water security
  • wastewater-based epidemiology
Open Researcher and Contributor ID (ORCID)



Neisseria gonorrhoeae drives Chlamydia trachomatis into a persistence-like state during in vitro co-infection
Infection and Immunity. 92(1) [DOI] 10.1128/iai.00179-23. [PMID] 38014981.
A multistate assessment of population normalization factors for wastewater-based epidemiology of COVID-19
PLOS ONE. 18(4) [DOI] 10.1371/journal.pone.0284370. [PMID] 37043469.
Retrospective Analysis of Wastewater-Based Epidemiology of SARS-CoV-2 in Residences on a Large College Campus: Relationships between Wastewater Outcomes and COVID-19 Cases across Two Semesters with Different COVID-19 Mitigation Policies
ACS ES&T Water. 3(1):16-29 [DOI] 10.1021/acsestwater.2c00275. [PMID] 37552720.
The infected and the affected: A longitudinal study of the impact of the COVID-19 pandemic on schoolchildren in Florida.
Frontiers in public health. 11 [DOI] 10.3389/fpubh.2023.1003923. [PMID] 36969651.
Assessment of a mass balance equation for estimating community-level prevalence of COVID-19 using wastewater-based epidemiology in a mid-sized city
Scientific Reports. 12(1) [DOI] 10.1038/s41598-022-21354-6. [PMID] 36352013.
Erratum: A CTS Team Approach to Wastewater-Based Epidemiology of Non-Typhoidal Salmonella in Gainesville, FL – ERRATUM.
Journal of clinical and translational science. 6(1) [DOI] 10.1017/cts.2022.416. [PMID] 36129420.
Wastewater surveillance for SARS-CoV-2 in a small coastal community: Effects of tourism on viral presence and variant identification among low prevalence populations.
Environmental research. 208 [DOI] 10.1016/j.envres.2021.112496. [PMID] 34902379.
What Is Motion? Recent Advances in the Study of Molecular Movement Patterns of the Peptidoglycan Synthesis Machines
Journal of Bacteriology. 204(4) [DOI] 10.1128/jb.00598-21. [PMID] 34928180.
Detection of SARS-CoV-2 in the gastrointestinal tract among patients with negative nasopharyngeal COVID-19 testing prior to endoscopy.
Endoscopy international open. 9(8):E1276-E1282 [DOI] 10.1055/a-1490-9234. [PMID] 34447876.
Psychosocial Health of K-12 Students Engaged in Emergency Remote Education and In-Person Schooling: A Cross-Sectional Study.
International journal of environmental research and public health. 18(16) [DOI] 10.3390/ijerph18168564. [PMID] 34444312.
Psychosocial health of school-aged children during the initial COVID-19 safer-at-home school mandates in Florida: a cross-sectional study.
BMC public health. 21(1) [DOI] 10.1186/s12889-021-10540-2. [PMID] 33781220.
Chlamydial MreB Directs Cell Division and Peptidoglycan Synthesis in Escherichia coli in the Absence of FtsZ Activity
mBio. 11(1) [DOI] 10.1128/mbio.03222-19.
Competing Substrates for the Bifunctional Diaminopimelic Acid Epimerase/Glutamate Racemase Modulate Peptidoglycan Synthesis in Chlamydia trachomatis
Infection and Immunity. 89(1) [DOI] 10.1128/iai.00401-20.
Fosmidomycin, an inhibitor of isoprenoid synthesis, induces persistence in Chlamydia by inhibiting peptidoglycan assembly.
PLoS pathogens. 15(10) [DOI] 10.1371/journal.ppat.1008078. [PMID] 31622442.
Chlamydia trachomatis dapF Encodes a Bifunctional Enzyme Capable of Both d -Glutamate Racemase and Diaminopimelate Epimerase Activities
mBio. 9(2) [DOI] 10.1128/mbio.00204-18.
A Brief History of Shigella.
EcoSal Plus. 8(1) [DOI] 10.1128/ecosalplus.ESP-0006-2017. [PMID] 29318984.
Distribution and characterization of Shiga toxin converting temperate phages carried by Shigella flexneri in Hispaniola
Infection, Genetics and Evolution. 65:321-328 [DOI] 10.1016/j.meegid.2018.07.038. [PMID] 30075254.
Evolution of Bacterial Pathogens Within the Human Host.
Microbiology spectrum. 4(1) [DOI] 10.1128/microbiolspec.VMBF-0017-2015. [PMID] 26999399.
Investigating the Relatedness of Enteroinvasive Escherichia coli to Other E. coli and Shigella Isolates by Using Comparative Genomics
Infection and Immunity. 84(8):2362-2371 [DOI] 10.1128/iai.00350-16.
Pathogenic Chlamydia Lack a Classical Sacculus but Synthesize a Narrow, Mid-cell Peptidoglycan Ring, Regulated by MreB, for Cell Division.
PLoS pathogens. 12(5) [DOI] 10.1371/journal.ppat.1005590. [PMID] 27144308.
Chlamydial variants differ in ability to ascend the genital tract in the guinea pig model of chlamydial genital infection.
Infection and immunity. 83(8):3176-83 [DOI] 10.1128/IAI.00532-15. [PMID] 26015484.
Phosphoproteomic analysis of the Chlamydia caviae elementary body and reticulate body forms.
Microbiology (Reading, England). 161(8):1648-1658 [DOI] 10.1099/mic.0.000116. [PMID] 25998263.
Prevalence of Shiga toxin-producing Shigella species isolated from French travellers returning from the Caribbean: an emerging pathogen with international implications.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 21(8):765.e9-765.e14 [DOI] 10.1016/j.cmi.2015.05.006. [PMID] 25980352.
Structural characterization of muropeptides from Chlamydia trachomatis peptidoglycan by mass spectrometry resolves “chlamydial anomaly”.
Proceedings of the National Academy of Sciences of the United States of America. 112(37):11660-5 [DOI] 10.1073/pnas.1514026112. [PMID] 26290580.
Stx-Producing Shigella Species From Patients in Haiti: An Emerging Pathogen With the Potential for Global Spread.
Open forum infectious diseases. 2(4) [DOI] 10.1093/ofid/ofv134. [PMID] 26484357.
A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis.
Nature. 506(7489):507-10 [DOI] 10.1038/nature12892. [PMID] 24336210.
Clinical isolates of Shiga toxin 1a-producing Shigella flexneri with an epidemiological link to recent travel to Hispañiola.
Emerging infectious diseases. 20(10):1669-77 [DOI] 10.3201/eid2010.140292. [PMID] 25271406.
Early microRNA expression profile as a prognostic biomarker for the development of pelvic inflammatory disease in a mouse model of chlamydial genital infection.
mBio. 5(3):e01241-14 [DOI] 10.1128/mBio.01241-14. [PMID] 24961692.
Potential novel antibiotics from HTS targeting the virulence-regulating transcription factor, VirF, from Shigella flexneri.
The Journal of antibiotics. 67(5):379-86 [DOI] 10.1038/ja.2014.10. [PMID] 24549153.
Promiscuous and adaptable enzymes fill “holes” in the tetrahydrofolate pathway in Chlamydia species.
mBio. 5(4):e01378-14 [DOI] 10.1128/mBio.01378-14. [PMID] 25006229.
Chlamydia trachomatis transports NAD via the Npt1 ATP/ADP translocase.
Journal of bacteriology. 195(15):3381-6 [DOI] 10.1128/JB.00433-13. [PMID] 23708130.
Antivirulence genes: insights into pathogen evolution through gene loss.
Infection and immunity. 80(12):4061-70 [DOI] 10.1128/IAI.00740-12. [PMID] 23045475.
Characterization of the activity and expression of arginine decarboxylase in human and animal Chlamydia pathogens.
FEMS microbiology letters. 337(2):140-6 [DOI] 10.1111/1574-6968.12021. [PMID] 23043454.
Effect of inflammatory response on in vivo competition between two chlamydial variants in the guinea pig model of inclusion conjunctivitis.
Infection and immunity. 80(2):612-9 [DOI] 10.1128/IAI.06054-11. [PMID] 22144478.
Uptake of biotin by Chlamydia Spp. through the use of a bacterial transporter (BioY) and a host-cell transporter (SMVT).
PloS one. 7(9) [DOI] 10.1371/journal.pone.0046052. [PMID] 23029384.
Identification and characterization of the Chlamydia trachomatis L2 S-adenosylmethionine transporter.
mBio. 2(3):e00051-11 [DOI] 10.1128/mBio.00051-11. [PMID] 21558433.
Chlamydia trachomatis serovar L2 can utilize exogenous lipoic acid through the action of the lipoic acid ligase LplA1.
Journal of bacteriology. 192(23):6172-81 [DOI] 10.1128/JB.00717-10. [PMID] 20870766.
Impact of azithromycin resistance mutations on the virulence and fitness of Chlamydia caviae in guinea pigs.
Antimicrobial agents and chemotherapy. 54(3):1094-101 [DOI] 10.1128/AAC.01321-09. [PMID] 20065052.
Microarray analysis of Shigella flexneri-infected epithelial cells identifies host factors important for apoptosis inhibition.
BMC genomics. 11 [DOI] 10.1186/1471-2164-11-272. [PMID] 20429941.
Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein.
Molecular microbiology. 71(2):350-68 [DOI] 10.1111/j.1365-2958.2008.06524.x. [PMID] 19017275.
Spa15 of Shigella flexneri is secreted through the type III secretion system and prevents staurosporine-induced apoptosis.
Infection and immunity. 77(12):5281-90 [DOI] 10.1128/IAI.00800-09. [PMID] 19805534.
The chlamydial functional homolog of KsgA confers kasugamycin sensitivity to Chlamydia trachomatis and impacts bacterial fitness.
BMC microbiology. 9 [DOI] 10.1186/1471-2180-9-279. [PMID] 20043826.
Transformation and isolation of allelic exchange mutants of Chlamydia psittaci using recombinant DNA introduced by electroporation.
Proceedings of the National Academy of Sciences of the United States of America. 106(1):292-7 [DOI] 10.1073/pnas.0806768106. [PMID] 19104068.
Staying alive: bacterial inhibition of apoptosis during infection.
Trends in microbiology. 16(4):173-80 [DOI] 10.1016/j.tim.2008.02.001. [PMID] 18353648.
The NleE/OspZ family of effector proteins is required for polymorphonuclear transepithelial migration, a characteristic shared by enteropathogenic Escherichia coli and Shigella flexneri infections.
Infection and immunity. 76(1):369-79 [PMID] 17984206.
Black holes, antivirulence genes, and gene inactivation in the evolution of bacterial pathogens.
FEMS microbiology letters. 267(1):1-8 [PMID] 17233672.
Frequency of development and associated physiological cost of azithromycin resistance in Chlamydia psittaci 6BC and C. trachomatis L2.
Antimicrobial agents and chemotherapy. 51(12):4267-75 [PMID] 17908942.
Genetic structure of the nadA and nadB antivirulence loci in Shigella spp.
Journal of bacteriology. 189(17):6482-6 [PMID] 17586625.
nadA and nadB of Shigella flexneri 5a are antivirulence loci responsible for the synthesis of quinolinate, a small molecule inhibitor of Shigella pathogenicity.
Microbiology (Reading, England). 153(Pt 7):2363-2372 [DOI] 10.1099/mic.0.2007/006916-0. [PMID] 17600080.
Shigella flexneri inhibits staurosporine-induced apoptosis in epithelial cells.
Infection and immunity. 75(5):2531-9 [PMID] 17339354.
Building the invisible wall: updating the chlamydial peptidoglycan anomaly.
Trends in microbiology. 14(2):70-7 [PMID] 16413190.
L,L-diaminopimelate aminotransferase, a trans-kingdom enzyme shared by Chlamydia and plants for synthesis of diaminopimelate/lysine.
Proceedings of the National Academy of Sciences of the United States of America. 103(47):17909-14 [PMID] 17093042.
OspF and OspC1 are Shigella flexneri type III secretion system effectors that are required for postinvasion aspects of virulence.
Infection and immunity. 74(10):5964-76 [PMID] 16988276.
Characterization of Chlamydia MurC-Ddl, a fusion protein exhibiting D-alanyl-D-alanine ligase activity involved in peptidoglycan synthesis and D-cycloserine sensitivity.
Molecular microbiology. 57(1):41-52 [PMID] 15948948.
Fitness cost due to mutations in the 16S rRNA associated with spectinomycin resistance in Chlamydia psittaci 6BC.
Antimicrobial agents and chemotherapy. 49(11):4455-64 [PMID] 16251283.
Frequency of spontaneous mutations that confer antibiotic resistance in Chlamydia spp.
Antimicrobial agents and chemotherapy. 49(7):2865-73 [PMID] 15980362.
Structure and biochemical analysis of a secretin pilot protein.
The EMBO journal. 24(6):1111-21 [PMID] 15775974.
A DNA adenine methylase mutant of Shigella flexneri shows no significant attenuation of virulence.
Microbiology (Reading, England). 150(Pt 4):1073-1078 [DOI] 10.1099/mic.0.26781-0. [PMID] 15073316.
Identification of two eukaryote-like serine/threonine kinases encoded by Chlamydia trachomatis serovar L2 and characterization of interacting partners of Pkn1.
Infection and immunity. 71(10):5772-84 [PMID] 14500499.
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
Journal of bacteriology. 185(4):1218-28 [PMID] 12562791.
Inhibition of Salmonella typhimurium enteropathogenicity by piperidine, a metabolite of the polyamine cadaverine.
The Journal of infectious diseases. 186(8):1122-30 [PMID] 12355363.
MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system.
Journal of bacteriology. 184(16):4409-19 [PMID] 12142411.
Cadaverine prevents the escape of Shigella flexneri from the phagolysosome: a connection between bacterial dissemination and neutrophil transepithelial signaling.
The Journal of infectious diseases. 184(6):743-53 [PMID] 11517436.
MxiM and MxiJ, base elements of the Mxi-Spa type III secretion system of Shigella, interact with and stabilize the MxiD secretin in the cell envelope.
Journal of bacteriology. 183(24):6991-8 [PMID] 11717255.
Pathoadaptive mutations that enhance virulence: genetic organization of the cadA regions of Shigella spp.
Infection and immunity. 69(12):7471-80 [PMID] 11705922.
Shigella flexneri LuxS quorum-sensing system modulates virB expression but is not essential for virulence.
Infection and immunity. 69(1):15-23 [PMID] 11119484.
Spa33, a cell surface-associated subunit of the Mxi-Spa type III secretory pathway of Shigella flexneri, regulates Ipa protein traffic.
Infection and immunity. 69(4):2180-9 [PMID] 11254573.
A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular dissemination.
Molecular microbiology. 34(4):675-89 [PMID] 10564508.
Establishment of unipolar localization of IcsA in Shigella flexneri 2a is not dependent on virulence plasmid determinants.
Infection and immunity. 67(1):350-6 [PMID] 9864236.
Inhibition of Shigella flexneri-induced transepithelial migration of polymorphonuclear leucocytes by cadaverine.
Cellular microbiology. 1(2):143-55 [PMID] 11207548.
The mxi-Spa type III secretory pathway of Shigella flexneri requires an outer membrane lipoprotein, MxiM, for invasin translocation.
Infection and immunity. 67(4):1982-91 [PMID] 10085046.
“Black holes” and bacterial pathogenicity: a large genomic deletion that enhances the virulence of Shigella spp. and enteroinvasive Escherichia coli.
Proceedings of the National Academy of Sciences of the United States of America. 95(7):3943-8 [PMID] 9520472.
Requirement of the Shigella flexneri virulence plasmid in the ability to induce trafficking of neutrophils across polarized monolayers of the intestinal epithelium.
Infection and immunity. 66(9):4237-43 [PMID] 9712773.
Shigella infection as observed in the experimentally inoculated domestic pig, Sus scrofa domestica.
Microbial pathogenesis. 25(4):189-96 [PMID] 9817822.
Virulence plasmid instability in Shigella flexneri 2a is induced by virulence gene expression.
Infection and immunity. 65(9):3686-92 [PMID] 9284138.
Effect of O side-chain length and composition on the virulence of Shigella flexneri 2a.
Molecular microbiology. 22(1):63-73 [PMID] 8899709.
Avirulence of rough mutants of Shigella flexneri: requirement of O antigen for correct unipolar localization of IcsA in the bacterial outer membrane.
Infection and immunity. 63(1):229-37 [PMID] 7528731.
Virulence protein export systems in Salmonella and Shigella: a new family or lost relatives?
Trends in cell biology. 4(7):240-2 [PMID] 14731663.
Environmental regulation of Shigella virulence.
Current topics in microbiology and immunology. 180:95-116 [PMID] 1324135.
mxiA of Shigella flexneri 2a, which facilitates export of invasion plasmid antigens, encodes a homolog of the low-calcium-response protein, LcrD, of Yersinia pestis.
Infection and immunity. 60(8):3287-95 [PMID] 1639496.
Temperature regulation of Shigella virulence: identification of the repressor gene virR, an analogue of hns, and partial complementation by tyrosyl transfer RNA (tRNA1(Tyr)).
Molecular microbiology. 6(15):2113-24 [PMID] 1406252.
Two novel virulence loci, mxiA and mxiB, in Shigella flexneri 2a facilitate excretion of invasion plasmid antigens.
Infection and immunity. 59(6):1997-2005 [PMID] 2037361.
Identification of an Escherichia coli gene homologous to virR, a regulator of Shigella virulence.
Journal of bacteriology. 171(5):2879-81 [PMID] 2651420.
Identification of Shigella invasion genes by isolation of temperature-regulated inv::lacZ operon fusions.
Infection and immunity. 57(10):2963-70 [PMID] 2674014.
Regulation of virulence genes in Shigella.
Molecular biology & medicine. 6(5):425-32 [PMID] 2696859.
Temperature regulation of virulence genes in pathogenic bacteria: a general strategy for human pathogens?
Microbial pathogenesis. 7(1):1-10 [PMID] 2682128.
Genetic determinants of Shigella pathogenicity.
Annual review of microbiology. 42:127-50 [PMID] 3059992.
Identification of a chromosomal gene controlling temperature-regulated expression of Shigella virulence.
Proceedings of the National Academy of Sciences of the United States of America. 85(8):2820-4 [PMID] 3282241.
Localization of plasmid loci necessary for the entry of Shigella flexneri into HeLa cells, and characterization of one locus encoding four immunogenic polypeptides.
Journal of general microbiology. 133(12):3403-13 [PMID] 2846749.
Multiplication of Shigella flexneri within HeLa cells: lysis of the phagocytic vacuole and plasmid-mediated contact hemolysis.
Infection and immunity. 51(2):461-9 [PMID] 3510976.
Cloning of plasmid DNA sequences involved in invasion of HeLa cells by Shigella flexneri.
Infection and immunity. 49(1):164-71 [PMID] 2989179.
Bacteriophage Mu d1(Apr lac) generates vir-lac operon fusions in Shigella flexneri 2a.
Infection and immunity. 45(3):642-8 [PMID] 6236150.
Loss of pigmentation in Shigella flexneri 2a is correlated with loss of virulence and virulence-associated plasmid.
Infection and immunity. 43(1):397-401 [PMID] 6360906.
Temperature-dependent expression of virulence genes in Shigella species.
Infection and immunity. 43(1):195-201 [PMID] 6360895.
Use of UV-irradiated bacteriophage T6 to kill extracellular bacteria in tissue culture infectivity assays.
Journal of immunological methods. 56(1):75-83 [PMID] 6338113.
Studies on the antigenic determinants of the Thy-1.2 alloantigen as expressed by the murine lymphoblastoid line S-49.1 TB-2-3.
Journal of immunology (Baltimore, Md. : 1950). 116(6):1669-72 [PMID] 58044.


Aug 2023 ACTIVE
Advanced Genetic Tools for Studying Chlamydia
Role: Principal Investigator
Apr 2020 ACTIVE
National Drug Early Warning System Coordinating Center
Role: Project Manager
Oct 2019 – Mar 2020
Quality Control Verification of Properties of Shigella flexneri 2a strain BS103
Role: Principal Investigator
Feb 2017 – Feb 2018
Sexually Transmitted Infection Surveillance in Urban and Rural Communities in Haiti
Role: Principal Investigator
Dec 2016 – Nov 2022
Peptidoglycan Assembly, Degradation, and Function in Pathogenic Chlamydia
Role: Principal Investigator
Jan 2016 – Jul 2018
Molecular Genetic Analysis of Chlamydia Pathogenicity
Role: Principal Investigator


Postdoctoral Fellow and Chargé de Recherche
1985 · Service des Entérobactéries, Institut Pasteur, Paris, France
Ph.D. – Molecular Cell Biology
1983 · University of Alabama in Birmingham
B.S. – Biology
1974 · Villanova University

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