Zhoumeng Lin

Zhoumeng Lin, BMed, PhD, DABT, CPH

Associate Professor

Department: HP-ENVIRONMENTAL GLOBAL HLTH
Business Phone: (352) 273-6160
Business Email: linzhoumeng@ufl.edu

About Zhoumeng Lin

Dr. Zhoumeng Lin is an Associate Professor in the Department of Environmental and Global Health and a member of the Center for Environmental and Human Toxicology. He received a B.Med. in Preventive Medicine from Southern Medical University in China in 2009 and a Ph.D. in Toxicology from the University of Georgia in 2013. He completed his postdoctoral training in the Institute of Computational Comparative Medicine at Kansas State University in 2016. He was an Assistant Professor from 2016 to 2021 and then an Associate Professor from March to May 2021 at Kansas State University, prior to joining the University of Florida as an Associate Professor in May 2021.

Dr. Lin’s research is focused on the development and application of computational technologies, especially physiologically based pharmacokinetic (PBPK) modeling, to study food safety, nanoparticle and chemical risk assessment. He is a co-author of more than sixty peer-reviewed publications. His publications have received several awards, including the Society of Toxicology Biological Modeling Specialty Section Best Paper Award in 2020.

Dr. Lin teaches a graduate level course on PBPK modeling every year. He is a co-editor and a co-author of five chapters of a recently published textbook entitled “Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment”.

Dr. Lin has served as an ad hoc grant reviewer for several agencies, including USDA and NIH. He is an ad hoc member of the Science Advisory Committee on Chemicals (SACC) of US EPA. He has served as an external reviewer on several risk assessment documents on different environmental chemicals for different agencies, including EPA, CDC, and FDA. He has been a member of Society of Toxicology since 2011. He served as a Sunday Host Mentor for the Sunday Undergraduate Education Program organized by the Committee on Diversity Initiatives of Society of Toxicology from 2016 to 2017 and he was a Secretary/Treasurer of Central States Society of Toxicology (CSSOT) from 2018 to 2020. He is now the Vice President-Elect of the Biological Modeling Specialty Section (BMSS) and a Councilor of the Nanoscience and Advanced Materials Specialty Section (NAMSS) of Society of Toxicology.

Accomplishments

Vice President-Elect, Biological Modeling Specialty Section
2021-2025 · Society of Toxicology
Councilor, Nanoscience and Advanced Materials Specialty Section
2021-2023 · Society of Toxicology
Best Paper Award of the Year 2020 (Honorable Mention)
2021 · Biological Modeling Specialty Section, Society of Toxicology
Best Paper Award of the Year 2019
2020 · Biological Modeling Specialty Section, Society of Toxicology
Co-Editor of the textbook "Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment"
2020 · Elsevier
Secretary/Treasurer, Central States Society of Toxicology
2018-2020 · Society of Toxicology

Board Certifications

  • Certified in Public Health (CPH)
    National Board of Public Health Examiners (NBPHE)
  • Diplomate of the American Board of Toxicology (DABT)
    American Board of Toxicology
  • Population PK/PD Pharmacometrician (Level 1) using Phoenix NLME 8.0 and 8.1
    Certara Professional Certification

Research Profile

Dr. Lin’s areas of expertise include Toxicology, Risk Assessment, Environmental Health, and Pharmacology. His research interest is in the development and application of computational technologies for environmental chemicals, nanoparticles and drugs in animals and humans to address research questions related to nanomedicine, animal-derived food safety assessment, and environmental chemical risk assessment. The computational technologies used in his research include physiologically based pharmacokinetic (PBPK), pharmacokinetics/pharmacodynamics (PK/PD), toxicogenomics, machine learning, and artificial intelligence (AI) approaches. The long-term goal of his research is to develop AI-assisted computational approaches to support decision-making in human health, animal health, and environmental health (i.e., one health approach).

Currently, there are three specific projects in his laboratory. The first project is to develop PBPK models for drugs in food-producing animals, such as cattle, swine, sheep, goats, chickens, turkeys, and fish. The second project is to develop AI-assisted PBPK models for nanoparticles in both healthy and tumor-bearing animals. The third project is develop PBPK models for environmental chemicals, such as per- and polyfluoroalkyl substances (PFAS) in animals and humans of different life stages.

Publications

2021
Analgesic Comparison of Flunixin Meglumine or Meloxicam for Soft-Tissue Surgery in Sheep: A Pilot Study.
Animals : an open access journal from MDPI. 11(2) [DOI] 10.3390/ani11020423. [PMID] 33562143.
2021
Determination of Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Parameters of Doxycycline against Edwardsiella ictaluri in Yellow Catfish (Pelteobagrus fulvidraco).
Antibiotics (Basel, Switzerland). 10(3) [DOI] 10.3390/antibiotics10030329. [PMID] 33800996.
2021
Development of a Gestational and Lactational Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctane Sulfonate (PFOS) in Rats and Humans and Its Implications in the Derivation of Health-Based Toxicity Values.
Environmental health perspectives. 129(3) [DOI] 10.1289/EHP7671. [PMID] 33730865.
2020
A physiologically based pharmacokinetic model of doxycycline for predicting tissue residues and withdrawal intervals in grass carp (Ctenopharyngodon idella).
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 137 [DOI] 10.1016/j.fct.2020.111127. [PMID] 31945393.
2020
A study to assess the correlation between plasma, oral fluid and urine concentrations of flunixin meglumine with the tissue residue depletion profile in finishing-age swine.
BMC veterinary research. 16(1) [DOI] 10.1186/s12917-020-02429-w. [PMID] 32571315.
2020
Clinical pharmacokinetics and outcomes of oral fluconazole therapy in dogs and cats with naturally occurring fungal disease.
Journal of veterinary pharmacology and therapeutics. 43(6):547-556 [DOI] 10.1111/jvp.12888. [PMID] 32656792.
2020
In vitro-in silico-based probabilistic risk assessment of combined exposure to bisphenol A and its analogues by integrating ToxCast high-throughput in vitro assays with in vitro to in vivo extrapolation (IVIVE) via physiologically based pharmacokinetic (PBPK) modeling.
Journal of hazardous materials. 399 [DOI] 10.1016/j.jhazmat.2020.122856. [PMID] 32937695.
2020
Incorporating Exogenous and Endogenous Exposures into Dietary Risk Assessment of Nitrates and Nitrites in Vegetables: A Probabilistic Integrated Toxicokinetic Modeling Approach.
Journal of agricultural and food chemistry. 68(4):1079-1090 [DOI] 10.1021/acs.jafc.9b06720. [PMID] 31885263.
2020
Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach.
ACS nano. 14(3):3075-3095 [DOI] 10.1021/acsnano.9b08142. [PMID] 32078303.
2020
Pharmacokinetic Parameters and Estimated Milk Withdrawal Intervals for Domestic Goats (Capra Aegagrus Hircus) After Administration of Single and Multiple Intravenous and Subcutaneous Doses of Flunixin Meglumine.
Frontiers in veterinary science. 7 [DOI] 10.3389/fvets.2020.00213. [PMID] 32509803.
2020
Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine.
Journal of veterinary pharmacology and therapeutics. 43(5):385-420 [DOI] 10.1111/jvp.12861. [PMID] 32270548.
2020
Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part II: Chicken and turkey.
Journal of veterinary pharmacology and therapeutics. [DOI] 10.1111/jvp.12931. [PMID] 33289178.
2020
Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part III: Sheep and goat.
Journal of veterinary pharmacology and therapeutics. [DOI] 10.1111/jvp.12938. [PMID] 33350478.
2020
Plasma concentrations of eleven cannabinoids in cattle following oral administration of industrial hemp (Cannabis sativa).
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-69768-4. [PMID] 32728233.
2020
Probabilistic human health risk assessment of perfluorooctane sulfonate (PFOS) by integrating in vitro, in vivo toxicity, and human epidemiological studies using a Bayesian-based dose-response assessment coupled with physiologically based pharmacokinetic (PBPK) modeling approach.
Environment international. 137 [DOI] 10.1016/j.envint.2020.105581. [PMID] 32087483.
2019
An integrated experimental and physiologically based pharmacokinetic modeling study of penicillin G in heavy sows.
Journal of veterinary pharmacology and therapeutics. 42(4):461-475 [DOI] 10.1111/jvp.12766. [PMID] 31012501.
2019
Assessing Global Human Exposure to T-2 Toxin via Poultry Meat Consumption Using a Lifetime Physiologically Based Pharmacokinetic Model.
Journal of agricultural and food chemistry. 67(5):1563-1571 [DOI] 10.1021/acs.jafc.8b07133. [PMID] 30633497.
2019
Bayesian evaluation of a physiologically based pharmacokinetic (PBPK) model for perfluorooctane sulfonate (PFOS) to characterize the interspecies uncertainty between mice, rats, monkeys, and humans: Development and performance verification.
Environment international. 129:408-422 [DOI] 10.1016/j.envint.2019.03.058. [PMID] 31152982.
2019
Development and application of a population physiologically based pharmacokinetic model for florfenicol and its metabolite florfenicol amine in cattle.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 126:285-294 [DOI] 10.1016/j.fct.2019.02.029. [PMID] 30825586.
2019
Effect of temperature on plasma and tissue kinetics of doxycycline in grass carp (Ctenopharyngodon idella) after oral administration
Aquaculture. 511 [DOI] 10.1016/j.aquaculture.2019.734204.
2019
Extralabel drug use in wildlife and game animals.
Journal of the American Veterinary Medical Association. 255(5):555-568 [DOI] 10.2460/javma.255.5.555. [PMID] 31429657.
2019
Integration of Food Animal Residue Avoidance Databank (FARAD) empirical methods for drug withdrawal interval determination with a mechanistic population-based interactive physiologically based pharmacokinetic (iPBPK) modeling platform: example for flunixin meglumine administration.
Archives of toxicology. 93(7):1865-1880 [DOI] 10.1007/s00204-019-02464-z. [PMID] 31025081.
2019
Methamphetamine produces cardiac damage and apoptosis by decreasing melusin.
Toxicology and applied pharmacology. 378 [DOI] 10.1016/j.taap.2019.03.015. [PMID] 30904475.
2019
Relative Oral Bioavailability of Two Amoxicillin-Clavulanic Acid Formulations in Healthy Dogs: A Pilot Study.
Journal of the American Animal Hospital Association. 55(1):14-22 [DOI] 10.5326/JAAHA-MS-6872. [PMID] 30427713.
2019
Tissue residue depletion and estimation of extralabel meat withdrawal intervals for tulathromycin in calves after pneumatic dart administration.
Journal of animal science. 97(9):3714-3726 [DOI] 10.1093/jas/skz231. [PMID] 31342061.
2019
Tissue residue depletion kinetics and withdrawal time estimation of doxycycline in grass carp, Ctenopharyngodon idella, following multiple oral administrations.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 131 [DOI] 10.1016/j.fct.2019.110592. [PMID] 31220539.
2019
Translating Nanomedicine to Comparative Oncology-the Case for Combining Zinc Oxide Nanomaterials with Nucleic Acid Therapeutic and Protein Delivery for Treating Metastatic Cancer.
The Journal of pharmacology and experimental therapeutics. 370(3):671-681 [DOI] 10.1124/jpet.118.256230. [PMID] 31040175.
2018
Bioavailability of suppository acetaminophen in healthy and hospitalized ill dogs.
Journal of veterinary pharmacology and therapeutics. 41(5):652-658 [DOI] 10.1111/jvp.12664. [PMID] 29756216.
2018
CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway.
Toxicology letters. 292:97-107 [DOI] 10.1016/j.toxlet.2018.04.027. [PMID] 29705343.
2018
Consequences of fipronil exposure in egg-laying hens.
Journal of the American Veterinary Medical Association. 253(1):57-60 [DOI] 10.2460/javma.253.1.57. [PMID] 29911954.
2018
Experimental challenges regarding the in vitro investigation of the nanoparticle-biocorona in disease states.
Toxicology in vitro : an international journal published in association with BIBRA. 51:40-49 [DOI] 10.1016/j.tiv.2018.05.003. [PMID] 29738787.
2018
Extralabel drug use in small ruminants.
Journal of the American Veterinary Medical Association. 253(8):1001-1009 [DOI] 10.2460/javma.253.8.1001. [PMID] 30272520.
2018
Methamphetamine exposure triggers apoptosis and autophagy in neuronal cells by activating the C/EBPβ-related signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. [DOI] 10.1096/fj.201701460RRR. [PMID] 29939784.
2018
Pharmacokinetics and Pharmacodynamics of Tildipirosin Against Pasteurella multocida in a Murine Lung Infection Model.
Frontiers in microbiology. 9 [DOI] 10.3389/fmicb.2018.01038. [PMID] 29867911.
2018
Probabilistic Physiologically Based Pharmacokinetic Model for Penicillin G in Milk From Dairy Cows Following Intramammary or Intramuscular Administrations.
Toxicological sciences : an official journal of the Society of Toxicology. 164(1):85-100 [DOI] 10.1093/toxsci/kfy067. [PMID] 29945226.
2018
Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling.
Nanotoxicology. 12(5):453-469 [DOI] 10.1080/17435390.2018.1459922. [PMID] 29658401.
2018
The construction and application of a population physiologically based pharmacokinetic model for methadone in Beagles and Greyhounds.
Journal of veterinary pharmacology and therapeutics. 41(5):670-683 [DOI] 10.1111/jvp.12676. [PMID] 29923612.
2017
Advance in physiologically based pharmacokinetic modelling: from the organ level to suborgan level based on experimental data.
The Journal of physiology. 595(24):7265-7266 [DOI] 10.1113/JP275311. [PMID] 29052221.
2017
Bacterial endotoxin (lipopolysaccharide) binds to the surface of gold nanoparticles, interferes with biocorona formation and induces human monocyte inflammatory activation.
Nanotoxicology. 11(9-10):1157-1175 [DOI] 10.1080/17435390.2017.1401142. [PMID] 29192556.
2017
Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 107(Pt A):74-87 [DOI] 10.1016/j.fct.2017.06.023. [PMID] 28627373.
2017
Effects of DDIT4 in Methamphetamine-Induced Autophagy and Apoptosis in Dopaminergic Neurons.
Molecular neurobiology. 54(3):1642-1660 [DOI] 10.1007/s12035-015-9637-9. [PMID] 26873849.
2017
Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic Reticulum Stress Signaling Pathway.
Frontiers in molecular neuroscience. 10 [DOI] 10.3389/fnmol.2017.00203. [PMID] 28694771.
2017
Performance Assessment and Translation of Physiologically Based Pharmacokinetic Models From acslX to Berkeley Madonna, MATLAB, and R Language: Oxytetracycline and Gold Nanoparticles As Case Examples.
Toxicological sciences : an official journal of the Society of Toxicology. 158(1):23-35 [DOI] 10.1093/toxsci/kfx070. [PMID] 28402537.
2017
Pharmacokinetics of Mequindox and Its Marker Residue 1,4-Bisdesoxymequindox in Swine Following Multiple Oral Gavage and Intramuscular Administration: An Experimental Study Coupled with Population Physiologically Based Pharmacokinetic Modeling.
Journal of agricultural and food chemistry. 65(28):5768-5777 [DOI] 10.1021/acs.jafc.7b01740. [PMID] 28640606.
2017
Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes.
Frontiers in molecular neuroscience. 10 [DOI] 10.3389/fnmol.2017.00409. [PMID] 29311802.
2016
A computational framework for interspecies pharmacokinetics, exposure and toxicity assessment of gold nanoparticles.
Nanomedicine (London, England). 11(2):107-19 [DOI] 10.2217/nnm.15.177. [PMID] 26653715.
2016
A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice.
Nanotoxicology. 10(2):162-72 [DOI] 10.3109/17435390.2015.1027314. [PMID] 25961857.
2016
DNA damage-inducible transcript 4 (DDIT4) mediates methamphetamine-induced autophagy and apoptosis through mTOR signaling pathway in cardiomyocytes.
Toxicology and applied pharmacology. 295:1-11 [DOI] 10.1016/j.taap.2016.01.017. [PMID] 26825372.
2016
Estimation of tulathromycin depletion in plasma and milk after subcutaneous injection in lactating goats using a nonlinear mixed-effects pharmacokinetic modeling approach.
BMC veterinary research. 12(1) [PMID] 27863483.
View on: PubMed
2016
Human Food Safety Implications of Variation in Food Animal Drug Metabolism.
Scientific reports. 6 [DOI] 10.1038/srep27907. [PMID] 27302389.
2016
Mathematical modeling and simulation in animal health – Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment.
Journal of veterinary pharmacology and therapeutics. 39(5):421-38 [DOI] 10.1111/jvp.12311. [PMID] 27086878.
2016
Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine.
Cell death & disease. 7 [DOI] 10.1038/cddis.2016.67. [PMID] 27031958.
2016
Role of PUMA in methamphetamine-induced neuronal apoptosis.
Toxicology letters. 240(1):149-60 [DOI] 10.1016/j.toxlet.2015.10.020. [PMID] 26524635.
2016
Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL/6 mice caused by chronic high-fat diet intake.
Physiology & behavior. 157:196-208 [DOI] 10.1016/j.physbeh.2016.02.007. [PMID] 26852949.
2015
A framework for meta-analysis of veterinary drug pharmacokinetic data using mixed effect modeling.
Journal of pharmaceutical sciences. 104(4):1230-9 [DOI] 10.1002/jps.24341. [PMID] 25641543.
2015
Caspase-11 plays an essential role in methamphetamine-induced dopaminergic neuron apoptosis.
Toxicological sciences : an official journal of the Society of Toxicology. 145(1):68-79 [DOI] 10.1093/toxsci/kfv014. [PMID] 25631491.
2015
Comparative In Vitro Cytotoxicity of 20 Potential Food Ingredients in Canine Liver, Kidney, Bone Marrow-Derived Mesenchymal Stem Cells, and Enterocyte-like Cells
Applied In Vitro Toxicology. 1(4):276-288 [DOI] 10.1089/aivt.2015.0020.
2015
Development and application of a multiroute physiologically based pharmacokinetic model for oxytetracycline in dogs and humans.
Journal of pharmaceutical sciences. 104(1):233-43 [DOI] 10.1002/jps.24244. [PMID] 25407474.
2015
Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modelling.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 32(12):2002-17 [DOI] 10.1080/19440049.2015.1100330. [PMID] 26414219.
2015
Neurochemical and electrophysiological deficits in the ventral hippocampus and selective behavioral alterations caused by high-fat diet in female C57BL/6 mice.
Neuroscience. 297:170-81 [DOI] 10.1016/j.neuroscience.2015.03.068. [PMID] 25849614.
2015
Pharmacokinetics of metallic nanoparticles.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. 7(2):189-217 [DOI] 10.1002/wnan.1304. [PMID] 25316649.
2015
Serum Vitamin D Levels and Polycystic Ovary syndrome: A Systematic Review and Meta-Analysis.
Nutrients. 7(6):4555-77 [DOI] 10.3390/nu7064555. [PMID] 26061015.
2014
Gestational and lactational exposure to atrazine via the drinking water causes specific behavioral deficits and selectively alters monoaminergic systems in C57BL/6 mouse dams, juvenile and adult offspring.
Toxicological sciences : an official journal of the Society of Toxicology. 141(1):90-102 [DOI] 10.1093/toxsci/kfu107. [PMID] 24913803.
2014
Insulin-like growth factor binding protein 5 (IGFBP5) mediates methamphetamine-induced dopaminergic neuron apoptosis.
Toxicology letters. 230(3):444-53 [DOI] 10.1016/j.toxlet.2014.08.010. [PMID] 25127757.
2014
Short-term oral atrazine exposure alters the plasma metabolome of male C57BL/6 mice and disrupts α-linolenate, tryptophan, tyrosine and other major metabolic pathways.
Toxicology. 326:130-41 [DOI] 10.1016/j.tox.2014.11.001. [PMID] 25445803.
2013
Differentiation state-dependent effects of in vitro exposure to atrazine or its metabolite diaminochlorotriazine in a dopaminergic cell line.
Life sciences. 92(1):81-90 [DOI] 10.1016/j.lfs.2012.10.027. [PMID] 23142650.
2013
Estimation of placental and lactational transfer and tissue distribution of atrazine and its main metabolites in rodent dams, fetuses, and neonates with physiologically based pharmacokinetic modeling.
Toxicology and applied pharmacology. 273(1):140-58 [DOI] 10.1016/j.taap.2013.08.010. [PMID] 23958493.
2013
Short-term atrazine exposure causes behavioral deficits and disrupts monoaminergic systems in male C57BL/6 mice.
Neurotoxicology and teratology. 39:26-35 [DOI] 10.1016/j.ntt.2013.06.002. [PMID] 23770127.
2011
A physiologically based pharmacokinetic model for atrazine and its main metabolites in the adult male C57BL/6 mouse.
Toxicology and applied pharmacology. 251(1):16-31 [DOI] 10.1016/j.taap.2010.11.009. [PMID] 21094656.

Grants

Sep 2021 ACTIVE
Development of a web-based predictive model of nanoparticle delivery to tumors by integrating physiologically-based pharmacokinetic modeling with artificial intelligence
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Sep 2021 ACTIVE
2021 FARAD
Role: Co-Investigator
Funding: US DEPT OF AG NATL INST OF FOOD AND AG
Sep 2021 ACTIVE
FARAD, aka Food Animal Residue Avoidance Databank
Role: Principal Investigator
Funding: UNIV OF CALIFORNIA DAVIS via US DEPT OF AG NATL INST OF FOOD AND AG
Aug 2021 ACTIVE
Physiologically based pharmacokinetic modeling and analysis of administration route-dependent tissue distribution of gold nanoparticles
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB

Education

Doctor of Philosophy (PhD) in Toxicology
2013 · University of Georgia
Bachelor of Medicine (BMed) in Preventive Medicine
2009 · Southern Medical University, Guangzhou, China

Contact Details

Phones:
Business:
(352) 273-6160
Emails: