Tracie R Baker

Tracie R Baker,

Associate Professor

Department: Department of Environmental and Global Health
Business Phone: (352) 273-9560
Business Email: tracie.baker@phhp.ufl.edu

About Tracie R Baker

Tracie R. Baker (DVM, PhD) has substantial academic training and research in developmental biology, environmental toxicology, genetics, and animal health. Her academic training has been multidisciplinary in nature with an interest in toxicology beginning as an undergraduate where she investigated water pollution effects and behavioral ecology. She earned her Master of Science at the University of Alaska – Fairbanks in marine biology. After earning her DVM (University of Wisconsin – Madison) and a certificate in fish health medicine from the State of Wisconsin, she was an assistant researcher investigating clinical improvements in fish medicine before accepting an NIEHS-funded postdoctoral position that evolved into a PhD program at UW – Madison where her research was the first to show transgenerational inheritance of disease using a zebrafish model. In 2013, she competed successfully for an NIH K01 award through the National Center for Advancing Translational Sciences (NCATS). Dr. Baker found that low level, dioxin-induced decreased fertility across multiple generations following early developmental exposure is mediated through the male germline. In 2016, She started her laboratory at Wayne State University (WSU) as an Assistant Professor in the Institute of Environmental Health Sciences and the Department of Pharmacology – School of Medicine, where she still conducts contaminant research in water and fish in the Great Lake region. In 2021, Dr. Baker joined the faculty at the University of Florida and continues to focus on One Health research evaluating developmentally-based and transgenerational, environmentally-induced disease of endocrine disrupting chemicals and contaminants of emerging concern. In her spare time, she enjoys spending time with her wife, kids, and their dogs, participating in open water swim events and triathlons, traveling, and being outside.

Related Links:

Accomplishments

Global Fellow
2023 · University of Florida

Teaching Profile

Courses Taught
2022,2024
PHC6722 Environmental and Global Health Research Methods Rotation
2022-2025
HSC4913 Supervised Research Experience
2022-2025
PHC6947 Environmental and Global Health Capstone Experience
2022-2023
PHC6313 Environmental Health Concepts in Public Health
2022-2024
PHC6937 Special Topics in Public Health
2023-2025
PHC7979 Advanced Research
2024-2025
HSC4970 Public Health and Health Professions Senior Honors Thesis
2024-2025
PHC7980 Research for Doctoral Dissertation
2024-2025
PHC6940 Master of Public Health Capstone
2024-2025
PHC6326 Environmental and One Health

Research Profile

The WATER (Warrior Aquatic, Translational, and Environmental Research) Lab is focused on multidisciplinary, translational research that seeks to bridge and improve human, animal, and environmental health. Our research goal is to provide critical insights into developmentally-based and transgenerational, environmentally-induced disease with primary emphasis on endocrine disrupting compounds, aquatic toxicants, and contaminants of emerging concern, while also developing novel methods and approaches in zebrafish husbandry, genomics, and behavior, as well as promoting standardization of the zebrafish model and continued improvements in care, welfare, and conservation of aquatic species and environments.

Open Researcher and Contributor ID (ORCID)

0000-0002-5057-4155

Areas of Interest
  • Aquatic Animal Medicine
  • Developmental Origins of Health and Disease
  • Ecotoxicology
  • Environmental Toxicology
  • Molecular Biology

Publications

Academic Articles
2024
Identification and quantification of novel per- and polyfluoroalkyl substances (PFAS) contamination in a Great Lakes urban-dominated watershed.
The Science of the total environment. 941 [DOI] 10.1016/j.scitotenv.2024.173325. [PMID] 38797403.
2024
Implications of Lead (Pb)-Induced Transcriptomic and Phenotypic Alterations in the Aged Zebrafish (Danio rerio).
Toxics. 12(10) [DOI] 10.3390/toxics12100745. [PMID] 39453165.
2024
Juvenile exposure to low-level 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters behavior and longitudinal morphometrics in zebrafish and F1 offspring.
Journal of developmental origins of health and disease. 15 [DOI] 10.1017/S2040174424000229. [PMID] 39397699.
2024
Multi- and Transgenerational Health Effects of Exposure to Toxicants in Fish
Toxicology of Fishes. Second Edition,CRC Press. 286-305
2024
Status of single-cell RNA sequencing for reproductive toxicology in zebrafish and the transcriptomic trade-off.
Current opinion in toxicology. 38 [DOI] 10.1016/j.cotox.2024.100463. [PMID] 38846809.
2024
Toxicity of microplastic fibers containing azobenzene disperse dyes to human lung epithelial cells cultured at an air-liquid interface
Journal of Hazardous Materials. 480 [DOI] 10.1016/j.jhazmat.2024.136280. [PMID] 39515142.
2023
Adult-Onset Transcriptomic Effects of Developmental Exposure to Benzene in Zebrafish (Danio rerio): Evaluating a Volatile Organic Compound of Concern.
International journal of molecular sciences. 24(22) [DOI] 10.3390/ijms242216212. [PMID] 38003401.
2023
Nonlethal detection of PFAS bioaccumulation and biomagnification within fishes in an urban- and wastewater-dominant Great Lakes watershed.
Environmental pollution (Barking, Essex : 1987). 321 [DOI] 10.1016/j.envpol.2023.121123. [PMID] 36681373.
2022
Comparative Toxicotranscriptomics of Single Cell RNA-Seq and Conventional RNA-Seq in TCDD-Exposed Testicular Tissue.
Frontiers in toxicology. 4 [DOI] 10.3389/ftox.2022.821116. [PMID] 35615540.
2022
Developmental Phenotypic and Transcriptomic Effects of Exposure to Nanomolar Levels of 4-Nonylphenol, Triclosan, and Triclocarban in Zebrafish (Danio rerio).
Toxics. 10(2) [DOI] 10.3390/toxics10020053. [PMID] 35202241.
2022
Evaluating Phenotypic and Transcriptomic Responses Induced by Low-Level VOCs in Zebrafish: Benzene as an Example.
Toxics. 10(7) [DOI] 10.3390/toxics10070351. [PMID] 35878256.
2022
Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio).
Toxics. 10(6) [DOI] 10.3390/toxics10060334. [PMID] 35736942.
2022
Point-of-use carbon-block drinking water filters change gut microbiome of larval zebrafish.
Environmental microbiology reports. 14(4):655-663 [DOI] 10.1111/1758-2229.13077. [PMID] 35521795.
2021
Adipocyte-driven unfolded protein response is a shared transcriptomic signature of metastatic prostate carcinoma cells.
Biochimica et biophysica acta. Molecular cell research. 1868(11) [DOI] 10.1016/j.bbamcr.2021.119101. [PMID] 34280426.
2021
Cisplatin-induced hair cell loss in zebrafish neuromasts is accompanied by protein nitration and Lmo4 degradation.
Toxicology and applied pharmacology. 410 [DOI] 10.1016/j.taap.2020.115342. [PMID] 33245977.
2021
Detection of endocrine disrupting chemicals in Danio rerio and Daphnia pulex: Step-one, behavioral screen.
Chemosphere. 271 [DOI] 10.1016/j.chemosphere.2020.129442. [PMID] 33476875.
2021
Developmental phenotypic and transcriptomic effects of exposure to nanomolar levels of metformin in zebrafish.
Environmental toxicology and pharmacology. 87 [DOI] 10.1016/j.etap.2021.103716. [PMID] 34311114.
2021
The phenotypic and transcriptomic effects of developmental exposure to nanomolar levels of estrone and bisphenol A in zebrafish.
The Science of the total environment. 757 [DOI] 10.1016/j.scitotenv.2020.143736. [PMID] 33243503.
2020
A Review of Volatile Organic Compound Contamination in Post-Industrial Urban Centers: Reproductive Health Implications Using a Detroit Lens.
International journal of environmental research and public health. 17(23) [DOI] 10.3390/ijerph17238755. [PMID] 33255777.
2020
Developmental exposure to Pb2+ induces transgenerational changes to zebrafish brain transcriptome.
Chemosphere. 244 [DOI] 10.1016/j.chemosphere.2019.125527. [PMID] 31816550.
2020
Nanoplastics impact the zebrafish (Danio rerio) transcriptome: Associated developmental and neurobehavioral consequences.
Environmental pollution (Barking, Essex : 1987). 266(Pt 2) [DOI] 10.1016/j.envpol.2020.115090. [PMID] 32693326.
2020
Removal efficiency of micro- and nanoplastics (180 nm-125 μm) during drinking water treatment.
The Science of the total environment. 720 [DOI] 10.1016/j.scitotenv.2020.137383. [PMID] 32325555.
2020
TCDD-induced multi- and transgenerational changes in the methylome of male zebrafish gonads.
Environmental epigenetics. 6(1) [DOI] 10.1093/eep/dvaa010. [PMID] 33214906.
2019
Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11.
Toxics. 7(4) [DOI] 10.3390/toxics7040050. [PMID] 31546644.
2019
Management of Multiple Protozoan Ectoparasites in a Research Colony of Axolotls (Ambystoma mexicanum).
Journal of the American Association for Laboratory Animal Science : JAALAS. 58(4):479-484 [DOI] 10.30802/AALAS-JAALAS-18-000111. [PMID] 31060645.
2019
Sox9 in mouse urogenital sinus epithelium mediates elongation of prostatic buds and expression of genes involved in epithelial cell migration.
Gene expression patterns : GEP. 34 [DOI] 10.1016/j.gep.2019.119075. [PMID] 31669249.
2019
Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster.
Biology open. 8(5) [DOI] 10.1242/bio.043372. [PMID] 31097444.
2018
Ancestral TCDD Exposure Induces Multigenerational Histologic and Transcriptomic Alterations in Gonads of Male Zebrafish.
Toxicological sciences : an official journal of the Society of Toxicology. 164(2):603-612 [DOI] 10.1093/toxsci/kfy115. [PMID] 29788325.
2018
Developmental Dioxin Exposure Alters the Methylome of Adult Male Zebrafish Gonads.
Frontiers in genetics. 9 [DOI] 10.3389/fgene.2018.00719. [PMID] 30687390.
2018
sox9b is required in cardiomyocytes for cardiac morphogenesis and function.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-32125-7. [PMID] 30224706.
2016
Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.
Zebrafish. 13(5):413-23 [DOI] 10.1089/zeb.2016.1275. [PMID] 27618130.
2014
Adverse effects in adulthood resulting from low-level dioxin exposure in juvenile zebrafish.
Endocrine disruptors (Austin, Tex.). 2(1) [DOI] 10.4161/endo.28309. [PMID] 26180821.
2014
Construction and characterization of a sox9b transgenic reporter line.
The International journal of developmental biology. 58(9):693-9 [DOI] 10.1387/ijdb.140288jp. [PMID] 25896205.
2014
Dioxin induction of transgenerational inheritance of disease in zebrafish.
Molecular and cellular endocrinology. 398(1-2):36-41 [DOI] 10.1016/j.mce.2014.08.011. [PMID] 25194296.
2014
Using zebrafish as a model system for studying the transgenerational effects of dioxin.
Toxicological sciences : an official journal of the Society of Toxicology. 138(2):403-11 [DOI] 10.1093/toxsci/kfu006. [PMID] 24470537.
2013
Comparative analgesic efficacy of morphine sulfate and butorphanol tartrate in koi (Cyprinus carpio) undergoing unilateral gonadectomy.
Journal of the American Veterinary Medical Association. 243(6):882-90 [DOI] 10.2460/javma.243.6.882. [PMID] 24004238.
2013
Early dioxin exposure causes toxic effects in adult zebrafish.
Toxicological sciences : an official journal of the Society of Toxicology. 135(1):241-50 [DOI] 10.1093/toxsci/kft144. [PMID] 23811824.
2004
Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0.
The Journal of biological chemistry. 279(26):27278-85 [PMID] 15075342.
2003
GTX(4) imposters: characterization of fluorescent compounds synthesized by Pseudomonas stutzeri SF/PS and Pseudomonas/Alteromonas PTB-1, symbionts of saxitoxin-producing Alexandrium spp.
Toxicon : official journal of the International Society on Toxinology. 41(3):339-47 [PMID] 12565757.
Presentations
2023-06-06
Persistent contaminants of emerging concern, including PFAS, in water, sediment, and fish in a Great Lakes urban-dominant watershed
National / Invited. Keynote. Detroit, MI
2023-04-04
“Developmental VOC exposure in zebrafish: Toxic mechanisms and biomarkers”.
Regional / Invited. Symposium.
2023-03-15
“Adverse health effects and induction of transgenerational inheritance of disease due to environmental contaminants using the zebrafish model”
Regional / Invited. Seminar.
2023-01-31
Adverse health effects and induction of transgenerational inheritance of disease due to environmental contaminants using the zebrafish model
Regional / Invited. Seminar.
2022-11-16
“PFAS and other contaminants of emerging concern in a Great Lakes urban-dominant watershed: implications for human and ecosystem health”
International / Invited. Speech.
2022-10-11
Adverse health effects and induction of transgenerational inheritance of disease due to environmental contaminants using the zebrafish model
Regional / Invited. Seminar.
2022-03-30
Zebrafish as a model for induction of transgenerational inheritance of disease in response to environmental contaminants
International / Invited. Speech.
2023-03-21
Behavioral and physiological effects of ancestral PFAS exposure on F3 zebrafish larvae. (Student presentation)
International / Invited. Poster. Nashville, TN.
2023-02-17
Behavioral and physiological effects of PFAS exposure on F3 zebrafish larvae (Student presentation)
State / Invited. Poster. Miami, FL
2022-10-26
Behavioral and physiological effects of PFAS exposure on F3 zebrafish larvae. (Student presentation)
Regional / Invited. Poster.
2023-03-23
Evaluating developmental effects of low-level benzene exposure in zebrafish (Student presentation)
International / Invited. Poster.
2023-02-09
Evaluating developmental effects of low-level benzene exposure in zebrafish (danio rerio). (Student presentation)
Regional / Invited. Speech.
2022-12-14
Evaluating developmental effects of low-level benzene exposure in zebrafish (danio rerio.) (Student presentation)
National / Invited. Poster. Raleigh, NC
2023-02-09
The effects of developmental exposure to 1,4-dioxane: A volatile organic compound (VOC) of concern. (Student presentation)
Regional / Invited. Poster.
2023-02-16
Nonlethal detection of PFAS bioaccumulation and biomagnification within fishes in a Great Lakes (Student presentation)Urban-Dominated Watershed (Student presentation)
State / Invited. Speech.
2023-03-21
Utilizing Novel methods to increase our ability to identify & quantify contamination of PFAS in a great lakes urban-dominated watershed (Student presentation)
International / Invited. Poster.
2023-04-14
Non-lethal Detection of PFAS Bioaccumulation and Biomagnification in Great Lakes Fish (Student Presentation)
Regional / Invited. Seminar.
2023-04-14
2022 Willoughby Expedition: presence of microplastics in a transect of Everglades water samples (Student presentation)
Regional / Invited. Poster.
2023-03-21
PFAS exposure in zebrafish dysregulates adult brain, gonad, liver and kidney transcriptome (Student presentation)
International / Invited. Poster. Nashville,TN
2024-05-23
“Environmental contamination through a One Health lens”
International / Invited. Keynote.
2023-11-16
Molecular insight into EDC-induced infertility in aquatic model systems
International / Invited. Speech.
2023-11-13
“Developmental phenotypic, transcriptomic, and multigenerational consequences of exposure to nanoplastics in zebrafish”
International / Invited. Speech.
2024-06-08
Multi-year detection of PFAS in environmental samples and multiple trophic levels in an urban and wastewater-dominant Great Lakes watershed
National / Invited. Poster.
2024-03-11
Molecular insight into EDC-induced infertility apical endpoints in aquatic model systems
International / Invited. Speech.
2024-03-12
Sublethal TCDD Exposure During Zebrafish Development Produces Multigenerational Abnormalities in Ovarian Histology and Gene Expression
International / Invited. Poster.
2024-03-12
Developmental exposure to TCDD alters sperm motility and whole-body hormone parameters in a zebrafish model
International / Invited. Poster.
2024-03-11
Investigation of low-level benzene-mediated early life exposure and adult-onset transcriptomic alterations in zebrafish (Danio rerio)
International / Invited. Poster.
2024-06-25
Investigation of low-level benzene-mediated transcriptomic alterations and endocrine disruption potential in zebrafish (Danio rerio)
International / Invited. Poster. Tuscany, Italy
2024-06-26
Molecular insight into EDC-induced adult-onset and transgenerational inheritance of disease using the zebrafish model
International / Invited. Speech. Tuscany, Italy
2024-06-24
Juvenile exposure to the model endocrine disruptor TCDD alters phenotypic, histologic, and genomic fertility apical endpoints in zebrafish
International / Invited. Poster. Italy
2024-06-24
Nanoplastic (NP) Induced Endocrine Mediated Behavioral, Reproductive, and Transcriptomic Disruption in Zebrafish Larvae That Persists into Adulthood
International / Invited. Poster.
2024-04-26
Monitoring of agricultural pesticides in surface and drinking water in the Oromia region of Ethiopia
Regional / Invited. Poster.
2024-04-26
Emerging Contaminants, Including Microplastics and PFAS, Discovered Across the Florida Everglades
Regional / Invited. Poster.
2024-04-26
Nanoplastic (NP) Induced Endocrine Disruption in Zebrafish Larvae That Persist into Adulthood
Regional / Invited. Poster.
2023-11-06
Adverse health effects and induction of transgenerational inheritance of disease due to environmental contaminants using the zebrafish model
State / Invited. Seminar.

Grants

Jul 2024 ACTIVE
Healthy Urban Waters: Holistic Analysis of CECs (Contaminants of Emerging Concern) in the Huron to Erie Corridor
Role: Principal Investigator
Funding: WAYNE STATE UNIV via FRED A AND BARBARA M ERB FAMILY FOU
Jul 2024 ACTIVE
Center for Leadership in Environmental Awareness & Research (CLEAR)
Role: Principal Investigator
Funding: WAYNE STATE UNIV via NATL INST OF HLTH NIEHS
Jul 2023 – Jun 2024
Center for Leadership in Environmental Awareness & Research (CLEAR)
Role: Principal Investigator
Funding: WAYNE STATE UNIV via NATL INST OF HLTH NIEHS
Jan 2023 ACTIVE
Transcriptomic and epigenetic mechanisms of lead (Pb)-induced neurobehavioral disease in aged populations and subsequent generations
Role: Principal Investigator
Funding: NATL INST OF HLTH NIEHS
Sep 2022 – Jun 2023
Center for Leadership in Environmental Awareness & Research (CLEAR)
Role: Principal Investigator
Funding: WAYNE STATE UNIV via NATL INST OF HLTH NIEHS
Nov 2021 ACTIVE
Genetic and epigenetic mechanisms of infertility caused by endocrine disrupting chemicals
Role: Principal Investigator
Funding: NATL INST OF HLTH NIEHS
Aug 2021 – May 2024
Healthy Urban Waters: Contaminants of Emerging Concern
Role: Principal Investigator
Funding: WAYNE STATE UNIV via FRED A AND BARBARA M ERB FAMILY FOU
Aug 2021 – Dec 2022
PFAS Health and Ecological Impacts
Role: Principal Investigator
Funding: WAYNE STATE UNIV via GREAT LAKES WATER AUTHORITY

Education

PhD in Molecular and Environmental Toxicology
2009-2013 · University of Wisconsin-Madison
DVM
2003-2008 · University of Wisconsin-Madison
MS Marine Biology
1997-2001 · University of Alaska-Fairbanks
BS Biology and Chemistry
1993-1997 · Cleveland State Universiity

Contact Details

Phones:
Business:
(352) 273-9560
Emails:
Addresses:
Business Mailing:
PO Box 100188
GAINESVILLE FL 32610
Business Street:
1225 CENTER DR
GAINESVILLE FL 32610

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