Tracie R Baker

Tracie R Baker,

Associate Professor

Department: Department of Environmental and Global Health
Business Phone: (352) 273-9560
Business Email: tracie.baker@ufl.edu

About Tracie R Baker

Tracie R. Baker (DVM, PhD) has substantial academic training and research in developmental biology, environmental toxicology, genetics, and animal health. Her academic training has been multidisciplinary in nature with an interest in toxicology beginning as an undergraduate at Cleveland State University, where she investigated water pollution effects on zebra mussel survival and behavioral ecology. She earned her Master of Science at the University of Alaska – Fairbanks while researching genes involved in toxin production by harmful algal blooms and bacterial species. After earning her DVM (University of Wisconsin – Madison) and a certificate in fish health medicine from the State of Wisconsin, she was an assistant researcher investigating clinical improvements in fish medicine before accepting an NIEHS-funded postdoctoral position that evolved into a PhD program at UW – Madison under the mentorship of Dr. Dick Peterson. Her research was the first to show transgenerational inheritance of disease using a zebrafish model. In 2013, she competed successfully for an NIH K01 award through the National Center for Advancing Translational Sciences (NCATS). Dr. Baker found that low level, dioxin-induced decreased fertility across multiple generations following early developmental exposure is mediated through the male germline, and has been invited to present these findings at several national and international conferences, including at several workshops hosted by the National Institutes of Health (NIH). In 2016, She started her laboratory at Wayne State University (WSU) as an Assistant Professor in the Institute of Environmental Health Sciences and the Department of Pharmacology – School of Medicine, where she still conducts contaminant research in water and fish in the Great Lake region. In 2021, Dr. Baker joined the faculty at the University of Florida and continues to focus on One Health research evaluating developmentally-based and transgenerational, environmentally-induced disease of endocrine disrupting chemicals and contaminants of emerging concern. In her spare time, she enjoys spending time with her wife, kids, and their dogs, participating in open water swim events and triathlons, traveling, and being outside.

Related Links:

Teaching Profile

Courses Taught
2022
PHC6722 Environmental and Global Health Research Methods Rotation
2022
HSC4913 Supervised Resrch Exp
2022-2023
PHC6947 Environmental and Global Health Capstone Experience
2022-2023
PHC6313 Environmental Health Concepts in Public Health
2022-2023
PHC6937 Special Topics in Public Health

Research Profile

The WATER (Warrior Aquatic, Translational, and Environmental Research) Lab is focused on multidisciplinary, translational research that seeks to bridge and improve human, animal, and environmental health. Our research goal is to provide critical insights into developmentally-based and transgenerational, environmentally-induced disease with primary emphasis on endocrine disrupting compounds, aquatic toxicants, and contaminants of emerging concern, while also developing novel methods and approaches in zebrafish husbandry, genomics, and behavior, as well as promoting standardization of the zebrafish model and continued improvements in care, welfare, and conservation of aquatic species and environments.

Open Researcher and Contributor ID (ORCID)

0000-0002-5057-4155

Publications

2022
Point‐of‐use carbon‐block drinking water filters change gut microbiome of larval zebrafish
Environmental Microbiology Reports. 14(4):655-663 [DOI] 10.1111/1758-2229.13077.
2022
Comparative Toxicotranscriptomics of Single Cell RNA-Seq and Conventional RNA-Seq in TCDD-Exposed Testicular Tissue.
Frontiers in toxicology. 4 [DOI] 10.3389/ftox.2022.821116. [PMID] 35615540.
2022
Developmental Phenotypic and Transcriptomic Effects of Exposure to Nanomolar Levels of 4-Nonylphenol, Triclosan, and Triclocarban in Zebrafish (Danio rerio)
Toxics. 10(2) [DOI] 10.3390/toxics10020053. [PMID] 35202241.
2022
Evaluating Phenotypic and Transcriptomic Responses Induced by Low-Level VOCs in Zebrafish: Benzene as an Example.
Toxics. 10(7) [DOI] 10.3390/toxics10070351. [PMID] 35878256.
2022
Insight into 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of zebrafish spermatogenesis via single cell RNA-seq
PNAS Nexus. 1(3) [DOI] 10.1093/pnasnexus/pgac060. [PMID] 35799832.
2022
Multi- and Transgenerational Effects of Developmental Exposure to Environmental Levels of PFAS and PFAS Mixture in Zebrafish (Danio rerio).
Toxics. 10(6) [DOI] 10.3390/toxics10060334. [PMID] 35736942.
2022
Sewage Transport Volumes and Physical Degradation Rates of Personal Care Wipes
JAWRA Journal of the American Water Resources Association. [DOI] 10.1111/1752-1688.13046.
2021
Adipocyte-driven unfolded protein response is a shared transcriptomic signature of metastatic prostate carcinoma cells.
Biochimica et biophysica acta. Molecular cell research. 1868(11) [DOI] 10.1016/j.bbamcr.2021.119101. [PMID] 34280426.
2021
Cisplatin-induced hair cell loss in zebrafish neuromasts is accompanied by protein nitration and Lmo4 degradation.
Toxicology and applied pharmacology. 410 [DOI] 10.1016/j.taap.2020.115342. [PMID] 33245977.
2021
Detection of endocrine disrupting chemicals in Danio rerio and Daphnia pulex: Step-one, behavioral screen.
Chemosphere. 271 [DOI] 10.1016/j.chemosphere.2020.129442. [PMID] 33476875.
2021
Developmental phenotypic and transcriptomic effects of exposure to nanomolar levels of metformin in zebrafish
Environmental Toxicology and Pharmacology. 87 [DOI] 10.1016/j.etap.2021.103716. [PMID] 34311114.
2021
The phenotypic and transcriptomic effects of developmental exposure to nanomolar levels of estrone and bisphenol A in zebrafish.
The Science of the total environment. 757 [DOI] 10.1016/j.scitotenv.2020.143736. [PMID] 33243503.
2020
A Review of Volatile Organic Compound Contamination in Post-Industrial Urban Centers: Reproductive Health Implications Using a Detroit Lens
International Journal of Environmental Research and Public Health. 17(23) [DOI] 10.3390/ijerph17238755. [PMID] 33255777.
2020
Developmental exposure to Pb2+ induces transgenerational changes to zebrafish brain transcriptome
Chemosphere. 244 [DOI] 10.1016/j.chemosphere.2019.125527. [PMID] 31816550.
2020
Nanoplastics impact the zebrafish (Danio rerio) transcriptome: Associated developmental and neurobehavioral consequences.
Environmental pollution (Barking, Essex : 1987). 266(Pt 2) [DOI] 10.1016/j.envpol.2020.115090. [PMID] 32693326.
2020
Removal efficiency of micro- and nanoplastics (180 nm–125 μm) during drinking water treatment
Science of The Total Environment. 720 [DOI] 10.1016/j.scitotenv.2020.137383. [PMID] 32325555.
2020
TCDD-induced multi- and transgenerational changes in the methylome of male zebrafish gonads
Environmental Epigenetics. 6(1) [DOI] 10.1093/eep/dvaa010. [PMID] 33214906.
2019
Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of hspb9 and hspb11.
Toxics. 7(4) [DOI] 10.3390/toxics7040050. [PMID] 31546644.
2019
Management of Multiple Protozoan Ectoparasites in a Research Colony of Axolotls (Ambystoma mexicanum).
Journal of the American Association for Laboratory Animal Science : JAALAS. 58(4):479-484 [DOI] 10.30802/AALAS-JAALAS-18-000111. [PMID] 31060645.
2019
Sox9 in mouse urogenital sinus epithelium mediates elongation of prostatic buds and expression of genes involved in epithelial cell migration.
Gene expression patterns : GEP. 34 [DOI] 10.1016/j.gep.2019.119075. [PMID] 31669249.
2019
Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster.
Biology open. 8(5) [DOI] 10.1242/bio.043372. [PMID] 31097444.
2018
Ancestral TCDD Exposure Induces Multigenerational Histologic and Transcriptomic Alterations in Gonads of Male Zebrafish
Toxicological Sciences. 164(2):603-612 [DOI] 10.1093/toxsci/kfy115. [PMID] 29788325.
2018
Developmental Dioxin Exposure Alters the Methylome of Adult Male Zebrafish Gonads.
Frontiers in genetics. 9 [DOI] 10.3389/fgene.2018.00719. [PMID] 30687390.
2018
sox9b is required in cardiomyocytes for cardiac morphogenesis and function.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-32125-7. [PMID] 30224706.
2016
Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.
Zebrafish. 13(5):413-23 [DOI] 10.1089/zeb.2016.1275. [PMID] 27618130.
2014
Adverse effects in adulthood resulting from low-level dioxin exposure in juvenile zebrafish.
Endocrine disruptors (Austin, Tex.). 2(1) [DOI] 10.4161/endo.28309. [PMID] 26180821.
2014
Construction and characterization of a sox9b transgenic reporter line.
The International journal of developmental biology. 58(9):693-9 [DOI] 10.1387/ijdb.140288jp. [PMID] 25896205.
2014
Dioxin induction of transgenerational inheritance of disease in zebrafish.
Molecular and cellular endocrinology. 398(1-2):36-41 [DOI] 10.1016/j.mce.2014.08.011. [PMID] 25194296.
2014
Using zebrafish as a model system for studying the transgenerational effects of dioxin.
Toxicological sciences : an official journal of the Society of Toxicology. 138(2):403-11 [DOI] 10.1093/toxsci/kfu006. [PMID] 24470537.
2013
Comparative analgesic efficacy of morphine sulfate and butorphanol tartrate in koi (Cyprinus carpio) undergoing unilateral gonadectomy.
Journal of the American Veterinary Medical Association. 243(6):882-90 [DOI] 10.2460/javma.243.6.882. [PMID] 24004238.
2013
Early dioxin exposure causes toxic effects in adult zebrafish.
Toxicological sciences : an official journal of the Society of Toxicology. 135(1):241-50 [DOI] 10.1093/toxsci/kft144. [PMID] 23811824.
2004
Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0.
The Journal of biological chemistry. 279(26):27278-85 [PMID] 15075342.
2003
GTX(4) imposters: characterization of fluorescent compounds synthesized by Pseudomonas stutzeri SF/PS and Pseudomonas/Alteromonas PTB-1, symbionts of saxitoxin-producing Alexandrium spp.
Toxicon : official journal of the International Society on Toxinology. 41(3):339-47 [PMID] 12565757.

Grants

Nov 2021 ACTIVE
Genetic and epigenetic mechanisms of infertility caused by endocrine disrupting chemicals
Role: Principal Investigator
Funding: NATL INST OF HLTH NIEHS
Aug 2021 ACTIVE
Healthy Urban Waters: Contaminants of Emerging Concern
Role: Principal Investigator
Funding: WAYNE STATE UNIV via FRED A AND BARBARA M ERB FAMILY FOU
Aug 2021 ACTIVE
PFAS Health and Ecological Impacts
Role: Principal Investigator
Funding: WAYNE STATE UNIV via GREAT LAKES WATER AUTHORITY

Contact Details

Phones:
Business:
(352) 273-9560
Emails:
Addresses:
Business Mailing:
PO Box 100188
GAINESVILLE FL 32610
Business Street:
1225 CENTER DR
GAINESVILLE FL 32610